Gibco™ Human I-309 (CCL1) Recombinant Protein, PeproTech®

Product Code. 17802333

Brand: Gibco™ 3003710UG

Description

Recombinant Protein

Recombinant Human I-309 is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8.

Specifications

• Accession Number: P22362
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 6346
• Molecular Weight (g/mol): 8.5 kDa
• Name: Human I-309 (CCL1)
• Quantity: 10 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: BF534335; C-C motif chemokine 1; C-C motif chemokine ligand 1; CCL 1; Ccl1; CCR8 ligand; chemokine (C-C motif) ligand 1; I-309; inflammatory cytokine I-309; P500; SCYA1; SISe; SIS-epsilon; small inducible cytokine A1; small inducible cytokine A1 (I-309, homologous to mouse Tca-3); small-inducible cytokine A1; T lymphocyte-secreted protein I-309; TCA3; TCA-3; T-cell activation protein 3
• Common Name: CCL1
• Gene Symbol: CCL1
• Biological Activity: Determined by its ability to chemoattract human monocytes population using a concentration range of 10.0-30.0 ng/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.