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ACROBiosystems Human Growth Hormone R (GHR) Protein, Fc Tag

Product Code. 15816837
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Quantity:
1 mg
50 μg
Unit Size:
1mg
50µg
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15816837 1 mg 1mg
15826837 50 μg 50µg
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Product Code. 15816837 Supplier ACROBiosystems Supplier No. GHRH52571MG

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Description

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.3 kDa. As a result of glycosylation, the protein migrates as 66-85 kDa under reducing (R) condition, and 135-160 kDa under non-reducing (NR) condition (SDS-P

Specifications

Accession Number P10912
Molecular Weight (g/mol) 54.3 kDa
Quantity 1 mg
Source Human GHR, Fc Tag (GHR-H5257) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Tyr 264 (Accession # P10912).
Immunogen Ala 27 - Tyr 264
Storage Requirements -20°C
Gene Alias GHR,GHBP,GH receptor
Common Name Growth Hormone R
Conjugate Unconjugated
Species Human
Protein Tag Fc Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Bio-Markers and CD Antigens
Purity or Quality Grade >95% as determined by SDS-PAGE
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