ACROBiosystems Human Gremlin / GREM1 Protein, His Tag

Product Code.	Quantity	unitSize
15846897	100 μg	100µg
15856897	1 mg	1mg

Product Code. 15846897 Supplier ACROBiosystems Supplier No. GR1H52H3100UG

Description

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.2 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

• Accession Number: NP_037504
• Molecular Weight (g/mol): 20.2 kDa
• Quantity: 100 μg
• Source: Human Gremlin, His Tag (GR1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 184 (Accession # NP_037504).
• Immunogen: Lys 25 - Asp 184
• Storage Requirements: -20°C
• Gene Alias: GREM1,CKTSF1B1,DAND2,DRM,PIG2
• Common Name: Gremlin
• Conjugate: Unconjugated
• Species: Human
• Protein Tag: His Tag
• Buffer: PBS, pH7.4 with 1 mM EDTA
• Endotoxin Level: Less than 1.0 EU / μg by the LAL method.
• Expression System: HEK293
• Form: Powder
• Protein Subtype: Cytokines and Growth Factors
• Purity or Quality Grade: >95% as determined by SDS-PAGE