Gibco™ Human Follistatin Recombinant Protein, PeproTech®

Product Code.	Quantity	unitSize
17831043	5 μg	5µg
17841043	100 μg	100µg
17830173	1 mg	1mg
17820283	20 μg	20µg
17891513	250 μg	250µg
17831323	500 μg	500µg

Product Code. 17831043 Supplier Gibco™ Supplier No. 120135UG

Description

Recombinant Protein

Recombinant Human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

Specifications

• Accession Number: P19883
• For Use With (Application): Control, Western Blot Control, ELISA Standard, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 10468
• Molecular Weight (g/mol): 31.5 kDa
• Name: Human Follistatin
• Purification Method: Purified
• Quantity: 5 μg
• Source: E. coli
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: activin-binding protein; AL033346; FOL1; Follictatin; Follistatin; follistatin isoform FST317; follistatin-A; FS; FST; Fst-288; RATFOL1
• Common Name: Follistatin
• Gene Symbol: Fst
• Biological Activity: Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 ug/ml in the presence of 7.5 ng/ml Activin A.
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCN
• Content And Storage: -20°C
• Activity: Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 ug/ml in the presence of 7.5 ng/ml Activin A.
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.