Gibco™ Human Epiregulin Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Brand:  Gibco™ 100-04-1MG

Product Code. 17830093

Description

Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

Specifications

• Accession Number: O14944
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 5.6
• Quantity: 1 mg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: Ereg
• Conjugate: Unconjugated
• Sequence: MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): Functional Assay
• Gene ID (Entrez): 2069
• Name: Human Epiregulin
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: Ep; Epiregulin; EPR; ER; EREG; Proepiregulin
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized