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Invitrogen™ Human ENSA (aa 1-36) Control Fragment Recombinant Protein

Product Code. 30196618
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30196618

Brand: Invitrogen™ RP101350

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (97%), Rat (97%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84060 (PA5-84060. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O43768
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 2029
Name Human ENSA (aa 1-36) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias 1700020C18Rik; 2610007F17Rik; AI451924; Alpha-endosulfine; ARPP-19 e; endosulfine alpha; endosulfine-alpha variant 1; endosulfine-alpha variant 3; ENSA
Common Name ENSA
Gene Symbol ENSA
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAK
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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