Invitrogen™ Human Cytokeratin 6A (aa 531-564) Control Fragment Recombinant Protein

Product Code. 30210646

Brand: Invitrogen™ RP103999

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (83%), Rat (83%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84483 (PA5-84483. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Specifications

• Accession Number: P02538
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 3853
• Name: Human Cytokeratin 6 A (aa 531-564) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: 2310016L08Rik; 60-kDa keratin; CK6A; CK-6 A; CK6C; CK-6 C; CK6D; CK-6 D; CK-6 E; cytokeratin 6 A; cytokeratin 6 C; cytokeratin 6 D; cytokeratin-6 A; cytokeratin-6 C; Cytokeratin-6 D; cytokeratin-6 E; Hom s 5; K6A; K6a keratin; K6C; K6D; kamp-keratin derived antimicrobial peptide; KDAMP; Ker2; keratin 6 A; keratin 6 A, , type II; keratin 6 A, type II; keratin complex 2, basic, gene 6 A; keratin complex 2, basic, gene 6 c; keratin complex 2, gene 6 A; keratin K6; keratin K6h; keratin, epidermal type II, K6A; keratin, type II cytoskeletal 6 A; keratin, type II cytoskeletal 6 C; Keratin-6 A; keratin-6-alpha; keratin-6 C; Krt2-6; Krt2-6 A; Krt2-6 c; Krt6; KRT6A; KRT6C; KRT6D; LOC683313; mK6[a]; MK6a; mK6-alpha; PC3; similar to keratin complex 2, basic, gene 6 A; type-II keratin Kb12; type-II keratin Kb6
• Common Name: Cytokeratin 6 A
• Gene Symbol: KRT6A
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: SGRAIGGGLSSVGGGSSTIKYTTTSSSSRKSYKH
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining