Invitrogen™ Human CYP3A7 (aa 321-348) Control Fragment Recombinant Protein

Product Code. 30209802

Brand: Invitrogen™ RP109485

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (79%), Rat (79%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-140177 (PA5-140177. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.

Specifications

• Accession Number: P24462
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 1551
• Name: Human CYP3A7 (aa 321-348) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: aryl hydrocarbon hydroxylase; CP37; CYP3A7; CYPIIIA7; Cytochrome P450 3A7; cytochrome P450 family 3 subfamily A member 7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450-HFLA; flavoprotein-linked monooxygenase; microsomal monooxygenase; P-450(HFL33); P-450111A7; P450-HFLA; P450HLp2; xenobiotic monooxygenase
• Common Name: CYP3A7
• Gene Symbol: CYP3A7
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: LATHPDVQQKVQKEIDTVLPNKAPPTYD
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining