Invitrogen™ Human CUG-BP2 (aa 293-373) Control Fragment Recombinant Protein

Product Code. 30199396

Brand: Invitrogen™ RP97001

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (83%), Rat (83%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.

Specifications

• Accession Number: O95319
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 10659
• Name: Human CUG-BP2 (aa 293-373) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: B230218O03; B230345P09Rik; BRUNOL3; Bruno-like protein 3; C88023; cb906; CELF 2; Celf2; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; Cugbp- and Etr3-like factor 2; CUGBP Elav-like family member 2; CUGBP, Elav-like family member 2; Cugbp2; CUG-BP2; cugbp2 protein; D230046B21Rik; elav-type ribonucleoprotein-3; elav-type RNA-binding protein 3; ETR3; ETR-3; fj87b07; hNAPOR; mETR-3; mNapor; NAPOR; napor protein isoform; napor protein long isoform; napor protein short isoform; Napor-2; neur; neuroblastoma apoptosis-related RNA-binding protein; RNA-binding protein; RNA-binding protein Brunol3; RNA-binding protein BRUNOL-3; rNapor; RP23-124P7.1; wu:fj87b07
• Common Name: CUG-BP2
• Gene Symbol: CELF2
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: TSTNANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGTINTPRSKRLLLPKDNNGM
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining