Invitrogen™ Human COP1 (aa 173-197) Control Fragment Recombinant Protein

Product Code. 30206264

Brand: Invitrogen™ RP101616

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (48%), Rat (48%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62890 (PA5-62890. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt]

Specifications

• Accession Number: Q5EG05
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 114769
• Name: Human COP1 (aa 173-197) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: CARD only domain-containing protein 1; CARD only protein; CARD16; CARD-only protein 1; caspase recruitment domain family member 16; caspase recruitment domain family, member 16; caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; caspase-1 inhibitor COP; Constitutive photomorphogenesis protein 1 homolog; constitutive photomorphogenic protein 1; COP; COP1; E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; hCOP1; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1 beta converting enzyme; PSEUDO-ICE; pseudo-IL1B-converting enzyme; putative ubiquitin ligase COP1; RFWD2; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2; RNF200
• Common Name: COP1
• Gene Symbol: CARD16
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: LHKGSLYPRIPGLGKELQTGTHKLS
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining