Invitrogen™ Human Connexin 31 (aa 218-267) Control Fragment Recombinant Protein

Product Code. 30207704

Brand: Invitrogen™ RP108002

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (56%), Rat (56%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Specifications

• Accession Number: O75712
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 2707
• Name: Human Connexin 31 (aa 218-267) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: Cn x 31; connexin 31; connexin-31; C x 31; Cxn-31; D4Wsu144e; DFNA2; DFNA2B; EKV; Gap junction beta-3 protein; gap junction membrane channel protein beta 3; gap junction protein beta 3; gap junction protein, beta 3; gap junction protein, beta 3, 31 kDa; Gjb3; Gjb-3
• Common Name: Connexin 31
• Gene Symbol: GJB3
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: LHKDKPRGGCSPSSSASRASTCRCHHKLVEAGEVDPDPGNNKLQASAPNL
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining