Invitrogen™ Human CMPK2 (aa 330-425) Control Fragment Recombinant Protein

Product Code. 30197953

Brand: Invitrogen™ RP110205

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (86%), Rat (86%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response.

Specifications

• Accession Number: Q5EBM0
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 129607
• Name: Human CMPK2 (aa 330-425) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: 1200004E04Rik; Cmpk2; cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; cytidine/uridine monophosphate kinase 2; cytidylate kinase 2; mitochondrial UMP-CMP kinase; NDK; Nucleoside-diphosphate kinase; TDKI; thymidine monophosphate kinase 2; thymidylate kinase family LPS-inducible member; thymidylate kinase homologue; thymidylate kinase LPS-inducible member; TMPK2; Tyki; UMP/CMP kinase; UMP-CMP kinase 2, mitochondrial; UMP-CMPK2
• Common Name: CMPK2
• Gene Symbol: CMPK2
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: DRYWHSTATYAIATEVSGGLQHLPPAHHPVYQWPEDLLKPDLILLLTVSPEERLQRLQGRGMEKTREEAELEANSVFRQKVEMSYQRMENPGCHVV
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining