Invitrogen™ Human Claudin 3 (aa 186-220) Control Fragment Recombinant Protein

Product Code. 30197806

Brand: Invitrogen™ RP91171

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (69%), Rat (69%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.

Specifications

• Accession Number: O15551
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 1365
• Name: Human Claudin 3 (aa 186-220) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: AI182374; C7orf1; claudin 3; claudin-3; CLDN3; clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-R2; CPE-receptor 2; CPETR2; hRVP1; integral membrane protein claudin-3; mRVP1; Rat ventral prostate0.1 protein; Rat ventral prostate0.1 protein homolog; RVP1; tight junction protein; ventral prostate0.1 protein; ventral prostate0.1 protein homolog; ventral prostate0.1-like protein
• Common Name: Claudin 3
• Gene Symbol: CLDN3
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: PREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining