Invitrogen™ Human CFHR5 ELISA Kit

Product Code. 17154849

Brand: Invitrogen™ EH104RBX5

Description

ELISA

Human CFHR5 quantitates human CFHR5 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CFHR5.

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Specifications

• Accession Number: CFHL5; CFHR5; CFHR5D; complement factor H related 5; complement factor H-related 5; complement factor H-related protein 5; factor H-related protein 5; FHR5; FHR-5
• Assay Range: 0.41 to 100 ng/mL
• Assay Sensitivity: 0.41 ng/mL
• Conjugate: HRP
• Product Type: ELISA
• Sample Type: Plasma, Serum, Supernatant
• For Use With (Equipment): Colorimetric Microplate Reader
• Gene ID (Entrez): 81494
• Gene Symbol: CFHR5
• Interassay CV: <12%
• Intraassay CV: <10
• Kit Contents: Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
• Label or Dye: HRP
• Quantity: 5 x 96 Tests
• Regulatory Status: RUO
• Sample Volume: Plasma 50 μL, Serum 50 μL, Supernatant 50 μL
• Storage Requirements: 2°C to 8°C
• Target: CFHR5
• Test Time: 1 hrs 20 mins
• Total Assay Time: 4 hrs 45 mins