Gibco™ Human CD200 Fc Recombinant Protein, PeproTech®

Product Code. 17954202

Brand: Gibco™ 310461MG

Description

Recombinant Protein

Recombinant Human CD200 Fc is a 97.0 kDa homodimeric protein of 435 amino acids consisting of the extracellular domain of the mature sequence, as well as a 230-residue C-terminal Fc region linked by two glycines. As a result of glycosylation, the Recombinant Human CD200 Fc migrates to an apparent molecular weight of approximately 60-70 kDa by SDS-PAGE gel, under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CD200 is a type-1 membrane glycoprotein that contains two immunoglobulin domains, and belongs to the immunoglobulin superfamily. CD200 is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) and is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Studies of the related genes in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms of CD200 have been found. Diseases associated with CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.

Specifications

• Accession Number: P41217
• For Use With (Application): Functional Assay
• Format: Lyophilized
• Formulation: protein with no preservative
• Gene ID (Entrez): 4345
• Molecular Weight (g/mol): 48.5 kDa
• Name: Human CD200 Fc
• Quantity: 1 mg
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-O x 2); Cspmo2; hypothetical protein LOC534910; MO x 1; MO x 2; MRC; MRC OX-2 antigen; MRCO x 2; My033; O x 2; OX-2; OX-2 membrane glycoprotein
• Common Name: CD200
• Biological Activity: Determined by its ability to bind Human CD200 R1 Fc in a functional ELISA.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: Fc-tag
• Sequence: Monomer: QVQVVTQDER EQLYTPASLK CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK FSEDHLNITC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGGGPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK
• Content And Storage: -20°C
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.