Invitrogen™ Human CD179b (aa 86-111) Control Fragment Recombinant Protein

Product Code. 30212946

Brand: Invitrogen™ RP106324

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (46%), Rat (46%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibodies, PA5-65649 (PA5-65649, PA5-67169 (PA5-67169. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The preB cell receptor, CD179b, is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation and differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Accession Number: P15814
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 3543
• Name: Human CD179b (aa 86-111) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: 14.1; AGM2; BB139905; CD179 antigen-like family member B; CD179b; CD179b antigen; ig lambda-5; IGL1; IGL5; Igl-5; IGLJ IGLL; IGLJ14.1; Igll; Igll1; IGO; IGVPB; immunoglobulin lambda chain 5; immunoglobulin lambda like polypeptide 1; immunoglobulin lambda-like polypeptide 1; immunoglobulin lambda-like polypeptide 5; Immunoglobulin omega polypeptide; immunoglobulin omega polypeptide chain; immunoglobulin-related 14.1 protein; immunoglobulin-related protein 14.1; lambda 5; lambda5; Pre-B lymphocyte-specific protein-2; VPREB2
• Common Name: CD179b
• Gene Symbol: IGLL1
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: GFQSKHNSVTHVFGSGTQLTVLSQPK
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining