Gibco™ Human CCL19 (MIP-3 beta) Recombinant Protein, PeproTech®

Produktkod. 30130964

Brand: Gibco™ 30029B01M

Beskrivning

Recombinant Protein

300-29B-1MG will be provided as 2 x 500 μg (300-29B-500UG). Recombinant Human MIP-3beta is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.

Specifikationer

• Accession Number: Q99731
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Format: Lyophilized
• Formulation: protein with no preservative
• Gene ID (Entrez): 6363
• Molecular Weight (g/mol): 8.8 kDa
• Name: Human CCL19 (MIP-3 beta)
• Quantity: 2 x 500 μg
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: beta chemokine exodus-3; beta-chemokine exodus-3; CC chemokine ligand 19; C-C motif chemokine; C-C motif chemokine 19; C-C motif chemokine ligand 19; Ccl19; chemokine (C-C motif) ligand 19; chemokine CCL19; CK beta-11; CKb11; EBI1 ligand chemokine; EBI-1 ligand chemokine; EBI1-ligand chemokine; EBV-induced molecule 1 ligand chemokine; ELC; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP3B; MIP-3 b; MIP-3-beta; M-MIP-3-beta; SCYA19; small inducible cytokine A19; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19
• Common Name: CCL19
• Biological Activity: Determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
• Content And Storage: -20°C
• Activity: Determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.