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Gibco™ Human C5a Recombinant Protein, PeproTech®

Product Code. 17812183
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Quantity:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
500 μg
Unit Size:
100µg
1mg
20µg
250µg
500µg
5µg
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Product Code. 17812183

Brand: Gibco™ 300701MG

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Description

Recombinant Protein

300-70-1MG will be provided as 2 x 500 μg (300-70-500UG). Recombinant Human C5a is an 8.3 kDa glycoprotein containing the 74 amino acid residues of the C5a anaphylatoxin chain. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01031
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 727
Molecular Weight (g/mol) 8.3
Name Human C5a
Quantity 2 x 500 μg
Source E. coli
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; C5; C5a; C5a anaphylatoxin; C5b; C5D; CH; CO4; complement C5; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain; complement component 5; CPAMD3; CPAMD4; DADB-112B14.11; ECLZB; FLJ17816; FLJ17822; FLJ60561; Hc; He; Hemolytic complement; MGC142298; MGC164979; prepro-C5; RGD1561905
Gene Symbol C5
Specific Reactivity Human
Conjugate Unconjugated
Recombinant Recombinant
Sequence TLQKKIEEIA AKYKHSVVKK CCYDGACVNN DETCEQRAAR ISLGPRCIKA FTECCVVASQ LRANISHKDM QLGR
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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