Gibco™ Human BMP-4 Recombinant Protein, PeproTech®

Product Code. 17821043

Brand: Gibco™ 120051UG

Description

Recombinant Protein

120-05-1MG will be provided as 10 x 100 μg (120-05-100UG). 120-05-500UG will be provided as 5 x 100 μg (120-05-100UG). Recombinant Human BMP-4, expressed in HeLa cells, is a 25.6 kDa homodimeric glycoprotein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Specifications

• Accession Number: P12644
• For Use With (Application): Control, Western Blot Control, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 652
• Molecular Weight (g/mol): 25.6 kDa
• Name: Human BMP-4
• Purification Method: Purified
• Quantity: 1 μg
• Source: HeLa cells
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: BMP; BMP2B; BMP-2B; Bmp2b1; Bmp2b-1; Bmp4; Bmp-4; BOMPR4A; Bone morphogenetic protein; Bone morphogenetic protein 2B; bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; DVR4; Dvr-4; MCOPS6; OFC11; ZYME
• Common Name: BMP4
• Gene Symbol: BMP4
• Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
• Content And Storage: -20°C
• Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
• Expression System: HeLa cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 97% by SDS-PAGE gel and HPLC analyses.