Gibco™ Human BMP-3 Recombinant Protein, PeproTech®

Product Code. 17830403

Brand: Gibco™ 12024B10UG

Description

Recombinant Protein

Recombinant Human BMP-3 is a disulfide-linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein. The calculated molecular weight of Recombinant Human BMP-3 is 25.2 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The BMPs belong to the TGF-Beta superfamilyBMPs stimulate the production of bone matrix proteins and thereby alter stromal cell and osteoclast proliferation, a key step in bone marrow development. In addition to promoting ectopic bone and cartilage development, BMPs regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. BMPs also play a role in dorsal/ventral patterning. BMP3, highly expressed in lung, ovary and small intestine, participates in cartilage and bone formation. BMP3 and BMP2 genes map to conserved regions between human and mouse.

Specifications

• Accession Number: P12645
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 651
• Molecular Weight (g/mol): 25.2 kDa
• Name: Human BMP-3
• Quantity: 10 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: 9130206H07; 9530029I04Rik; BMP; Bmp3; Bmp-3; BMP3A; BMP-3 A; Bone morphogenetic protein; Bone morphogenetic protein 3; bone morphogenetic protein 3 (osteogenic); bone morphogenetic protein 3 A; bone morphogenetic protein-3; osteogenin; PBMP3
• Common Name: BMP-3
• Gene Symbol: BMP3
• Biological Activity: Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPMPKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD ENKNVVLKVY PNMTVESCAC R
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.