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Invitrogen™ Human APC11 (aa 18-99) Control Fragment Recombinant Protein

Product Code. 30199556
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30199556

Brand: Invitrogen™ RP93302

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (28%), Rat (28%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55709 (PA5-55709. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. [UniProt]
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9NYG5
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 51529
Name Human APC11 (aa 18-99) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias 1110011I19Rik; Anapc11; anaphase promoting complex subunit 11; anaphase promoting complex subunit 11 (yeast APC11 homolog); anaphase promoting complex subunit 11 homolog; anaphase-promoting complex subunit 11; APC11; APC11 anaphase promoting complex subunit 11 homolog; Apc11p; Cyclosome subunit 11; hepatocellular carcinoma-associated RING finger protein; HSPC214; R75218; RGD1561880
Common Name APC11
Gene Symbol ANAPC11
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence ANDENCGICRMAFNGCCPDCPLHGESISRCLGWCPQPVPVLGGRAHPQVPINTASPTPGQHTGSLMSREESSRSPDPTPPAL
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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