Abnova™ Human ANPEP (967 amino acids) native Protein from human serum

Product Code. 16058076

Brand: Abnova™ P4918.10ug

Description

Used for Func, SDS-PAGE

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq]

Specifications

• For Use With (Application): Functional Study, SDS-PAGE
• Formulation: In 20mM Tris-HCl, 500mM NaCl, 1mM CaCl
• Gene ID (Entrez): 290
• Molecular Weight (g/mol): 110-130kDa
• Name: ANPEP (Human) Native Protein
• Preparation Method: Native protein purified from human serum
• Purification Method: Saltprecipitation/Ion Exchange Chromatography/Gelfiltration
• Quality Control Testing: 15% SDS-PAGE Stained with Coomassie Blue
• Quantity: 10 ug
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Gene Alias: APN/CD13/LAP1/PEPN/gp150/p150
• Common Name: ANPEP
• Gene Symbol: ANPEP
• Biological Activity: > 500mU/mg (L-Leu-pNA at 37°C, pH 7.2).
• Species: Human
• Protein Tag: None
• Expression System: Native protein purified from human serum
• Form: Liquid
• Purity or Quality Grade: >90% by SDS-PAGE