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Gibco™ Human Amphiregulin Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Brand:  Gibco™ 100-55B-100UG

Additional Details : Weight : 0.16500kg

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Product Code. 17830103

  • £240.00 / 100µg
Estimated Shipment: 09-08-2024
to see stock.

Description

Description

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
Specifications

Specifications

P15514
protein with no preservative
11.3
100 μg
-20°C
<1 EU/μg
AREG
Unconjugated
SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK
≥ 95% by SDS-PAGE gel and HPLC analyses.
ELISA, Functional Assay, Western Blot
374
Human Amphiregulin
E. coli
RUO
amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF
Human
Recombinant
Lyophilized
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