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Invitrogen™ Human 4E-BP2 (aa 81-115) Control Fragment Recombinant Protein

Product Code. 30209084
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30209084

Brand: Invitrogen™ RP102764

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This item is not returnable. View return policy

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57941 (PA5-57941. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

PHAS-II (eIF4E-binding protein II) is involved in translation initiation. PHAS-II is highest in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA in vitro and in cells. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation initiation. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II. Thus, PHAS proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q13542
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 1979
Name Human 4 E-BP2 (aa 81-115) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias 2810011I19Rik; 4 EBP2; 4 E-BP2; AA792569; BC010348; eIF4E-binding protein 2; EIF4EBP2; eukaryotic translation initiation factor 4 E binding protein 2; eukaryotic translation initiation factor 4 E-binding protein 2; PHASII; PHAS-II; Phosphorylated heat- and acid-stable protein regulated by insulin 2; phosphorylated, heat and acid stable regulated by insulin protein II
Common Name 4 E-BP2
Gene Symbol EIF4EBP2
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence VTSPGTLIEDSKVEVNNLNNLNNHDRKHAVGDDAQ
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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