Gibco™ Human 4-1BB Ligand (TNFSF9), Animal-Free Recombinant Protein, PeproTech®

Product Code. 17873743

Brand: Gibco™ AF310111MG

Description

Recombinant Protein

Recombinant Human 4-1BB Ligand is a soluble 19.5 kDa protein consisting of 185 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

Specifications

• Accession Number: P41273
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 8744
• Molecular Weight (g/mol): 19.5 kDa
• Name: Human 4-1 BB Ligand (TNFSF9), Animal-Free
• Quantity: 1 mg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <0.1 EU/ μg
• Gene Alias: 4 1 BB Ligand; 4 1 BBL; 41 BB Ligand; 4-1 BB ligand; 41 BBL; 4-1 BBL; 4-1 BB-L; AI848817; CD 137 Ligand; CD 137 L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1 BB-L; Ly63l; receptor 4-1 BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5 A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9
• Common Name: 4-1 BBL (CD137L)
• Gene Symbol: TNFSF9
• Biological Activity: Determined by its ability to induce CD137/NF-kappaB activation in HEK293 reporter cells.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.