Invitrogen™ hu14.18-IL2 Biosimilar Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30283652	Invitrogen™ MA559449	100 μg
30284532	Invitrogen™ MA559450	1 mg

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °. This antibody can also be cross referenced by the term EMD 273063.

Hu14.18-IL2 is a humanized monoclonal antibody covalently linked to two interleukin-2 (IL-2) molecules. The hu14.18 component specifically targets GD2, a disialoganglioside abundantly expressed on tumor cells, especially in neuroblastoma and melanoma. Meanwhile, IL-2 stimulates the proliferation and activation of immune cells such as natural killer (NK) cells and T cells. GD2, also known as GD2 ganglioside, is a tumor-associated glycolipid antigen that is overexpressed in a variety of cancers, particularly those derived from neuroectodermal tissues. Structurally, GD2 contains three carbohydrate residues and two sialic acids bonded to a ceramide tail, which is embedded in the outer plasma membrane. This compound plays a critical role in cell surface glycosylation changes during malignant transformation and is ranked high as a target for cancer vaccine development.

Specifications

• Antigen: hu14.18-IL2 Humanized Biosimilar
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Lyophilized
• Isotype: IgG1
• Target Species: Human
• Primary or Secondary: Primary
• Purification Method: Protein A

• Concentration: 1 mg/mL
• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Conjugate: Unconjugated
• Host Species: Human
• Regulatory Status: RUO
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Product Type: Antibody