Invitrogen™ HTR1B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA533292

Product Code. 15334721

Description

Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Bat, Horse, Pig (94%); Hamster, Panda, Bovine, Dog, Cat, Rabbit, Guinea pig (88%); Elephant, Opossum (82%). For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.

Specifications

• Antigen: HTR1B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HTR1B
• Gene Alias: 5-HT>1B> receptor; 5ht1b; 5-HT1B; 5-HT-1B; 5HT1B Receptor; 5-HT1B receptor; 5-HT1B serotonin receptor; 5-HT1DB; 5-HT-1D-beta; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; HTR1B; HTR1D2; HTR1DB; S12; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin 1D beta receptor; Serotonin receptor 1B
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3351
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P28222
• Gene Symbols: HTR1B
• Immunogen: Synthetic 17 amino acid peptide from internal region of human 5HT1B Receptor.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Monkey
• Product Type: Antibody
• Isotype: IgG