HSP90 Monoclonal Antibody (AC-16), APC, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA545115

Product Code. 17838402

Description

1 μg/mL of MA5-45115 was sufficient for detection of HSP90 in 20 μg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody∣Detects 90kDa. This antibody is reactive with both the constitutive and the inducible form of HSP90. It does not bind to the native form and does not recognize HSP90 from E.coli or yeast.

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

Specifications

• Antigen: HSP90
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
• Gene Accession No.: P07900, P07901, P08238, P11499, P11501, P30946, P30947, P34058, P82995, Q04619
• Gene Symbols: HSP90AA1, HSP90AB1
• Immunogen: Heat shock protein 90 from the water mold Achyla ambisexualis
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Chicken, Fungi, Human, Insect, Mouse, Plant, Rabbit, Rat
• Form: Liquid

• Applications: Microarray, Immunohistochemistry (PFA fixed), Western Blot
• Clone: AC-16
• Conjugate: APC
• Gene: HSP90AB1
• Gene Alias: 86kDa; 89kDa; 90kDa; 90-kDa heat shock protein; 90-kDa heat shock protein alpha; 90-kDa heat shock protein beta; AL022974; AL024080; AL024147; C81438; D6S182; EL52; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; heat shock 84 kDa; Heat shock 86 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 86; heat shock protein 90 alpha (cytosolic), class B member 1; heat shock protein 90 alpha family class A member 1; heat shock protein 90 alpha family class B member 1; heat shock protein 90 beta; heat shock protein 90 kDa; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 9
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100338694, 100358690, 15516, 15519, 299331, 301252, 3320, 3326, 396188, 423463
• Content And Storage: 4° C
• Isotype: IgG2b