Invitrogen™ HSD3B2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA576669

Product Code. 15973185

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

3 beta-hydroxysteroid dehydrogenase (3beta-HSD), also known as HSD3B1 or HSDB3, is a bifunctional enzyme that plays a crucial role in the synthesis of all classes of hormonal steroids. Two human 3beta-HSD proteins, designated type I (3beta-HSD) and type II (3beta-HSD2), are expressed by different genes and function in different areas of the body. Localized to the membrane of the endoplasmic reticulum (ER) and expressed in skin and placenta, 3beta-HSD is the type I protein that catalyzes the oxidative conversion of delta5-ene-3-beta-hydroxy steroid, as well as the conversion of various ketosteroids. Defects in the gene encoding 3beta-HSD are associated with classic salt wasting, genital ambiguity, hypogonadism, insulin-resistant polycystic ovary syndrome (PCOS) and an increased susceptibility to prostate cancer. Additionally, congenital deficiency of 3beta-HSD activity results in a severe depletion of steroid formation which can be lethal in young children.

Specifications

• Antigen: HSD3B2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HSD3B2
• Gene Alias: 3 beta HSD II; 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase 2; 3 beta-hydroxysteroid dehydrogenase 6; 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3beta-HSD; 3-beta-HSD adrenal and gonadal type; 3-beta-HSD II; 3-beta-HSD IV; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; delta 5-delta 4-isomerase type II; Delta-5-3-ketosteroid isomerase; HSD3B; Hsd3b1; Hsd3b2; Hsd3b6; HSD-3beta; HSDB; HSDB3B; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6; hydroxysteroid dehydrogenase-2, delta>5>-3-beta; hydroxysteroid dehydrogenase-6 delta>5>-3-beta; progesterone reductase; SDR11E2; short chain dehydrogenase/reductase family 11E, member 2; Steroid Delta-isomerase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15493, 3284
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 1% BSA, 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: P26149, P26439
• Gene Symbols: HSD3B2
• Immunogen: KLH conjugated synthetic peptide derived from human HSD3B1+ HSD3B2: 101-200.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG