HSD11B2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16832724	Proteintech 14192-1-AP-20UL	20 μL
16822724	Proteintech 14192-1-AP-150UL	150 μL

Description

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Specifications

• Antigen: HSD11B2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Rat, Mouse, Human
• Gene Accession No.: P50233, P51661, P80365
• Gene ID (Entrez): 15484, 25117, 3291
• Immunogen: HSD11B2 Fusion Protein Ag5146
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: HSD11B2

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: 11 beta HSD2, 11 DH2, AME, AME1, HSD11B2, HSD11K, HSD2, SDR9C3
• Gene Symbols: HSD11B2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody