Invitrogen™ HSD11B1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA542758

Product Code. 15555662

Description

Peptide sequence: QKVVSHCLEL GAASAHYIAG TMEDMTFAEQ FVAQAGKLMG GLDMLILNHI Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 93%.

HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: HSD11B1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hsd11b1
• Gene Alias: 11 beta-hydroxysteroid dehydrogenase type 1; 11beta-HSD type 1; 11-beta-HSD1; 11beta-HSD1; 11beta-HSD-1; 11beta-HSD1A; 11-beta-hydroxysteroid dehydrogenase; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase type 1; 11beta-hydroxysteroid dehydrogenase type 1; 11-DH; Corticosteroid 11-beta-dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A); cortocosteroid 11-beta dehydrogenase; CORTRD2; HDL; HSD11; HSD11B; Hsd11b1; HSD11L; hydroxysteroid (11-beta) dehydrogenase 1; hydroxysteroid 11-beta dehydrogenase 1; hydroxysteroid dehydrogenase, 11 beta type 1; LRRGT00065; MGC13539; OTTHUMP00000034650; SDR26C1; short chain dehydrogenase/reductase family 26C member 1; short chain dehydrogenase/reductase family 26C, member 1; short-chain reductase; short-chain reductase/dehydrogenase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25116, 3290
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Surface Plasmon Resonance
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P16232, P28845
• Gene Symbols: Hsd11b1
• Immunogen: Synthetic peptide directed towards the N-terminal of human HSD11B1 (aa 72-121).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG