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Hsc70 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16807173 Shop All Proteintech Products
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150 μL
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150µL
20µL
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16807173 150 μL 150µL
16817173 20 μL 20µL
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Product Code. 16807173 Supplier Proteintech Supplier No. 106541AP150UL

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Description

Rabbit Polyclonal Antibody

The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.

Specifications

Antigen Hsc70
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.28 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene HSPA8
Gene Accession No. P11142, P63017, P63018
Gene Alias HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, HSPA8
Gene Symbols Hspa8
Host Species Rabbit
Immunogen Hsc70 Fusion Protein Ag1018
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15481, 24468, 3312
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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