Invitrogen™ HRI Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5115166

Product Code. 17217933

Description

Antibody detects endogenous levels of total EIF2AK1.

EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.

Specifications

• Antigen: HRI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EIF2AK1
• Gene Alias: EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; hemin-sensitive initiation factor 2a kinase; hemin-sensitive initiation factor 2-alpha kinase; Hri; KIAA1369; PRO1362
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15467, 27102
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9BQI3, Q9Z2R9
• Gene Symbols: EIF2AK1
• Immunogen: A synthesized peptide derived from human EIF2AK1(Accession Q9BQI3), corresponding to amino acid residues I575-K625.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG