Invitrogen™ HRI Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA589632

Product Code. 16577461

Description

Positive Samples: A-431, SH-SY5Y; Cellular Location: Cytoplasm Immunogen sequence: SIVEQQLPLR RNSHLEESFT STEESSEENV NFLGQTEAQY HLMLHIQMQL CELSLWDWIV ERNKRGREYV DESACPYVMA NVATKIFQEL VEGVFYIHNM GIVHRDLKPR NIFLHGPDQQ VKIGDFGLAC TDILQKNTDW TNRNGKRTPT HTSRVGTCLY ASPEQLEGSE YDAKSDMYSL GVVLLELFQP FGTEMERAEV LTGLRTGQLP ESLRKRCPVQ AKYIQHLTRR NSSQRPSAIQ LLQSELFQNS.

EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.

Specifications

• Antigen: HRI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EIF2AK1
• Gene Alias: EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; hemin-sensitive initiation factor 2a kinase; hemin-sensitive initiation factor 2-alpha kinase; Hri; KIAA1369; PRO1362
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27102, 27137
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.93 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q63185, Q9BQI3
• Gene Symbols: EIF2AK1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 337-586 of human EIF2AK1 (NP_0552282).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG