Invitrogen™ HRD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582191

Product Code. 16379154

Description

Immunogen sequence: PAPGFPFPPP WMGMPLPPPF AFPPMPVPPA GFAGLTPEEL RALEGHERQH LEARLQSLRN IHTLLDAAML QINQYLTVLA SLGPPRPATS VNSTEETATT VVAAASSTSI PSSEATTPTP GASPPAPEME RPPAPESVGT Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 90%.

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

Specifications

• Antigen: HRD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SYVN1
• Gene Alias: 1200010C09Rik; AW211966; C85322; D530017H19Rik; DER3; E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog; Hrd1; HRD1 protein; KIAA1810; MGC40372; RGD1310488; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin; synoviolin 1; Syvn1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84447
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86TM6
• Gene Symbols: SYVN1
• Immunogen: Recombinant protein corresponding to Human SYVN1. Recombinant protein control fragment (Product #RP-89210).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG