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HPI 1, Tocris Bioscience™

Product Code. 18768617
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Product Code. 18768617 Supplier Tocris Bioscience Supplier No. 3839/10

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Description

Inhibits Hedgehog signaling

Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 599150-20-6
Molecular Formula C27H29NO6
Molecular Weight (g/mol) 463.53
InChI Key ZXSWZQSYZYMZKS-UHFFFAOYSA-N
Synonym hpi-1, hpi 1, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-4,6,7,8-tetrahydro-1h-quinoline-3-carboxylate, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphe nyl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, 1,4,5,6,7,8-hexahydro-4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-1,4,6,7, 8-pentahydroquinoline-3-carboxylate, 3-quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-, 2-methoxyethyl ester
PubChem CID 2926768
IUPAC Name 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
SMILES CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC

Specifications

Quantity 10 mg
Formula Weight 463.52
Percent Purity >95%
Chemical Name or Material HPI 1
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