Invitrogen™ HP1 beta Recombinant Human Monoclonal Antibody (RAB-C145)

Human Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA551855

Product Code. 30088840

Description

This antibody recognizes CBX1 (Chromobox protein homolog 1). It binds to a folded domain, amino acids 20-73. CBX1 is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Specifications

• Antigen: HP1 beta
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: P83916
• Gene Symbols: CBX1
• Immunogen: This antibody was obtained by recombinant antibody (rAb) phage display recognizing CBX1 protein under non-denaturing conditions.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: F(ab) κ

• Applications: ChIP Assay, ELISA, Immunocytochemistry, Mass Spectrometry
• Clone: RAB-C145
• Conjugate: Unconjugated
• Gene: CBX1
• Gene Alias: CBX; Cbx1; Cbx-rs2; chromobox 1; chromobox homolog 1; chromobox homolog 1 (HP1 beta homolog Drosophila ); chromobox protein homolog 1; E430007M08Rik; heterochromatin protein 1 homolog beta; heterochromatin protein 1-beta; heterochromatin protein p25; heterochromatin protein p25 beta; HGNC:1551; HP1 beta; HP1 beta homolog; HP1B; Hp1beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta; M31; MOD1; modifier 1 protein; p25beta
• Host Species: Human
• Purification Method: Metal-chelate chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10951
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid