HNRNPA1 Rabbit anti-Human, Mouse, Porcine, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 11176-1-AP-20UL

Code produit. 16868073

Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Spécification

• Antigen: HNRNPA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HNRNPA1
• Gene Alias: Helix destabilizing protein, hnRNP A1, hnRNP core protein A1, HNRNPA1, HNRPA1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15382, 3178, 768103
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot, Immunocytochemistry
• Concentration: 0.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P09651, P49312
• Gene Symbols: HNRNPA1
• Immunogen: HNRNPA1 Fusion Protein Ag1656
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Human, Pig
• Product Type: Antibody
• Isotype: IgG