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HLA-G, PE, clone: 87G, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 12-9957-42
Code : NEW
Additional Details : Weight : 0.23750kg
Description
Description: The monoclonal antibody 87G recognizes human HLA-G, a member of the Human Leukocyte Antigen family but as part of the nonclassical MHC type involved in inhibiting immune reponses. HLA-G has seven reported isoforms. The antibody 87G recognizes both HLA-G1 and the solube HLA-G5. Expression of HLA-G is found primarily in fetal trophoblast cells as they invade the maternal decidua thereby protecting the fetus from the maternal immune system. Like the highly mitotic trophoblast, abundant HLA-G protein expression has been identified in some tumors, including melanoma, breast carcinoma and renal carcinoma as well as CLL, AML and B-CLL. Some expression has also been found in pancreatic islets, erythroid and endothelial progenitors and the adult thymic medulla.HLA-G+ CD4 or CD8 cells have been identified in normal human peripheral blood and are thought to act as regulatory cells in that they are hypoproliferative with a unique cytokine profile differing from Tregs. The receptors for HLA-G are CD85j/ILT2, CD85d/ILT4, and CD158. Recent studies have shown a role for HLA-G in tolerance and maintenance of transplanted organs.Applications Reported: This 87G antibody has been reported for use in flow cytometric analysis.Applications Tested: This 87G antibody has been pre-titrated and tested by flow cytometric analysis of stimulated U937 cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.Specifications
HLA-G | |
Monoclonal | |
5μl/Test | |
PBS with 0.2% BSA, 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
P17693 | |
DADB-15K14.8, MHC-G | |
Murine | |
Affinity chromatography | |
RUO | |
Antibody | |
Monoclonal | |
Human |
Flow Cytometry | |
87G | |
PE | |
HLA-G | |
Conjugated | |
HLA-G | |
IgG2a, kappa | |
100 Tests | |
Store at 2-8°C. Do not freeze. Light-sensitive material. | |
Primary | |
3135 |
For Research Use Only.