Invitrogen™ HLA-DQB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5140258

Product Code. 17894770

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: GRSIEDWNNY KDFLEQERAA VDKVCRHNYE AELRTTLQRQ VEPTVTIS Highest antigen sequence indentity to the following orthologs: Rat - 50%, Mouse - 52%.

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DQB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HLA-DQB2
• Gene Alias: DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)); HLA class II histocompatibility antigen, DQ beta 2 chain; HLA class II histocompatibility antigen, DX beta chain; HLA-DQB1; HLA-DQB2; HLA-DXB; major histocompatibility complex, class II, DQ beta 1; major histocompatibility complex, class II, DQ beta 2; MHC class II antigen DQB2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3120
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P05538
• Gene Symbols: HLA-DQB2
• Immunogen: Recombinant protein corresponding to Human HLA-DQB2. Recombinant protein control fragment (Product #RP-109326).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG