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Invitrogen™ HLA-DOB Polyclonal Antibody
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Product Code. 15584171
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
15584171 100 μL 100µL
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Product Code. 15584171 Supplier Invitrogen™ Supplier No. PA536963

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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 31 kDa. Purity is >95% by SDS-PAGE.

Peptide (antigen) binding to major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II-Ig dimers and by the activity of MHC molecules HLA-DM and -DO. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HLA-DOB
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene HLA-DOB
Gene Accession No. P13765
Gene Alias DOB; HLA class II histocompatibility antigen, DO beta chain; HLA-DO beta; HLA-DOB; major histocompatibility complex, class II, DO beta; MHC class II antigen DOB
Gene Symbols HLA-DOB
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the 43-88 of human HLA-DOB.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3112
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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