HLA-DMB Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16831305	Proteintech 21704-1-AP-20UL	20 μL
16821305	Proteintech 21704-1-AP-150UL	150 μL

Description

HLA-DMB (major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is encoded by the HLA-DMB gene. The HLA-DMB gene is mapped on 6p21.32. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation.

Specifications

• Antigen: HLA-DMB
• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P28068
• Gene ID (Entrez): 3109
• Immunogen: HLA-DMB Fusion Protein Ag16320
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: HLA-DMB

• Concentration: 0.38 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: D6S221E, DMB, HLA DMB, HLA-DMB, MHC class II antigen DMB, RING7
• Gene Symbols: HLA-DMB
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody