HLA class I (HLA-B) Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16827124	Proteintech 17260-1-AP-20UL	20 μL
16817124	Proteintech 17260-1-AP-150UL	150 μL

Description

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Specifications

• Antigen: HLA class I (HLA-B)
• Applications: Immunoprecipitation, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P01889
• Gene ID (Entrez): 3106
• Immunogen: HLA class I (HLA-B) Fusion Protein Ag10947
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: HLA-B

• Concentration: 0.29 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: AS, HLA B, HLA B 7301, HLA B73, HLAB, HLA-B, HLAC, MHC class I antigen B*7, SPDA1
• Gene Symbols: HLA-B
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody