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Invitrogen™ Histone Core Polyclonal Antibody
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Product Code. 11565843
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Quantity:
125 μg
Unit Size:
125µg
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Product Code. Quantity unitSize
11565843 125 μg 125µg
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Product Code. 11565843 Supplier Invitrogen™ Supplier No. PA128375

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Description

Sheep Polyclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The histone core is an integral component of chromatin structure, consisting of an octamer of core histones: H2A, H2B, H3, and H4. Each nucleosome unit contains two copies of each of these histones, forming a structural foundation around which approximately 147 base pairs of DNA are wrapped. The histone octamer is organized with an (H3-H4)2 tetramer at its core, flanked by two H2A-H2B dimers. This highly conserved structure not only facilitates DNA compaction but also plays a critical role in regulating gene expression through various post-translational modifications, such as acetylation, methylation, and phosphorylation. These modifications can alter chromatin dynamics and accessibility, impacting processes such as transcription, replication, and DNA repair. The presence of specific histone variants further adds to the epigenetic complexity and regulation of the genome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Histone Core
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 2.42 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene H4C2
Gene Accession No. P62803, Q5E9F8
Gene Alias core histone macro-H2A.1; H2A histone family, member Y; H2AFY; H2B; H2B clustered histone 19; H2B clustered histone 8; H2BC19; H2BC8; H3 histone, family 3A; H3.3 histone A; H3-3A; H3-3B; H3F3A; H3F3B; H4; H4 clustered histone 2; H4.1; H4C2; histone H2B; histone H2B type 1; histone H2B type 2-E; histone H2B-like; histone H3.3; Histone H4; histone H4.1; macroH2A.1 histone; MACROH2A1; similar to H2A histone family, member Y isoform 2; similar to H3 histone, family 3A
Gene Symbols H2B, H3-3A, H4C2, MACROH2A1
Host Species Sheep
Immunogen Intact calf histone core - rRNA complex.
Purification Method Protein G
Quantity 125 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 280691, 326601, 519934, 532990, 615043, 787581
Target Species Bovine
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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