Invitrogen™ His6-DEP-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587692

Product Code. 16566121

Description

Immunogen sequence: KSNDTAASEY KYVVKHKMEN EKTITVVHQP WCNITGLRPA TSYVFSITPG IGNETWGDPR VIKVITEPIP VSDLRVALTG VRKAALSWSN GNGTASCRVL LESIGSHEEL TQDSRLQVNI SGLKPGVQYN INPYLLQSNK TKGDPLGTEG GLDASNTERS RAGSPTAPVH DESLVGPVDP SSGQQSRDTE VLLVGLEPGT RYNATVYSQA ANGTEGQPQA IEFRTNAIQV F; Positive Samples: Raji, SW480, Mouse spleen; Cellular Location: Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, ruffle membrane.

The protein encoded by His6-DEP-1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for His6-DEP-1.

Specifications

• Antigen: His6-DEP-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTPRJ
• Gene Alias: AI450271; BET; Byp; CD148; CD148 antigen; colon tumor susceptibility 1; density-enhanced phosphatase 1; DEP1; DEP-1; HPTP beta-like tyrosine phosphatase; HPTP eta; HPTPeta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type J; protein tyrosine phosphatase, receptor type, J; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; Ptpb2; PTPbeta2; PTPRJ; Receptor-type tyrosine-protein phosphatase eta; R-PTP-ETA; RPTPJ; R-PTP-J; Scc1; Scc-1; Susceptibility to colon cancer 1; susceptibility to colon cancer 1, mouse, homolog of
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19271, 5795
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q12913, Q64455
• Gene Symbols: PTPRJ
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 140-370 of human PTPRJ (NP_0028343).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG