Invitrogen™ HIRA Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA565749

Product Code. 15968484

Description

Immunogen sequence: TWNLVSDKQDS LAQCADFRSS LPSQDAMLCS GPLAIIQGRT SNSGRQAARL FSVPHVVQQE TTLAYLENQV AAALTLQSSH EYRHWLLVYA RYLVNEGFEY RLREICKDLL GPVHYSTG Highest antigen sequence identity to the following orthologs - mouse 97%, rat 95%.

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Specifications

• Antigen: HIRA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HIRA
• Gene Alias: AA138857; D16Ertd95e; DGCR1; DiGeorge critical region gene 1; Gm15797; HIR; HIR histone cell cycle regulation defective homolog A; Hira; histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulator; N28177; OTTMUSG00000026264; Protein HIRA; TUP1; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; TUPLE1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7290
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P54198
• Gene Symbols: HIRA
• Immunogen: Recombinant Human HIRA. Recombinant protein control fragment (Product #RP-106426).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG