Invitrogen™ HIPPI Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA519110

Product Code. 11387083

Description

This antibody is predicted to react with bovine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Specifications

• Antigen: HIPPI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IFT57
• Gene Alias: 4833420A15Rik; dermal papilla-derived protein 8; DERP8; Esrrbl1; estrogen-related receptor beta like 1; estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; Hippi; huntingtin interacting protein-1 interacting protein; huntingtin-interacting protein-1 protein interactor; IFT57; intraflagellar transport 57; intraflagellar transport 57 homolog; intraflagellar transport protein 57 homolog; MHS4R2; Vestrogen-related receptor beta like 1
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 55081, 73916
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8BXG3, Q9NWB7
• Gene Symbols: IFT57
• Immunogen: Synthetic peptide sequence (EQPQEYDDPNATISN ) corresponding to the internal amino acids of IFT57 (aa 103-117).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG