Invitrogen™ HIP55 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582988

Product Code. 16379944

Description

Immunogen sequence: PPEQETFYEQ PPLVQQQGAG SEHIDHHIQG QGLSGQGLCA RALYDYQAAD DTEISFDPEN LITGIEVIDE GWWRGYGPDG H Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 86%.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Specifications

• Antigen: HIP55
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DBNL
• Gene Alias: Abp1; Actin-binding protein 1; cervical mucin-associated protein; Cervical SH3P7; CMAP; DBNL; dbnl {ECO:0000312; drebrin F; drebrin like; drebrin-F; drebrin-like; drebrin-like protein; EMBL:AAH72483.1}; HIP55; HIP-55; HPK1-interacting protein of 55 kDa; mAbp1; PP5423; SH3 domain-containing protein 7; Sh3p7; src homology 3 domain-containing protein HIP-55
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13169, 28988, 83527
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q62418, Q9JHL4, Q9UJU6
• Gene Symbols: DBNL
• Immunogen: Recombinant protein corresponding to Human DBNL. Recombinant protein control fragment (Product #RP-92734).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG