Invitrogen™ HINT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5120074

Product Code. 17751474

Description

Positive test controls include: 22Rv1, HeLa, H460, K-562, Mouse kidney, Mouse liver, Rat kidney, Rat liver. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG.

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.

Specifications

• Antigen: HINT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hint1
• Gene Alias: 17 kDa inhibitor of protein kinase C; AA673479; Adenosine 5'-monophosphoramidase; FLJ30414; FLJ32340; HINT; Hint1; histidine triad nucleotide binding protein 1; histidine triad nucleotide-binding protein 1; Ipk1; NMAN; PKC inhibitor/ interacting protein; Pkci; PKCI1; PKCI-1; Prkci; PRKCNH1; protein kinase C inhibitor 1; protein kinase C, iota; protein kinase C-interacting protein 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15254, 3094, 690660
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.8 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P49773, P62959, P70349
• Gene Symbols: Hint1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human HINT1 (NP_005331.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG