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HIF-1α (Hypoxia-Inducible Factor-1α) Ab-4, Mouse Monoclonal Antibody,Lab Vision™ Epredia™
Recommended for Immunohistochemistry (Formalin/paraffin), Epredia™ HIF-1α (Hypoxia-Inducible Factor-1α) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.
Brand: Epredia MS-1164-P0
This item is not returnable.
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Description
HIF-1 (hypoxia-inducible factor-1) is a heterodimer consisting of an alpha and a β subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. HIF-1 is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation. HIF-1 activates transcription of hypoxia-inducible genes, including those encoding: erythropoietin, vascular endothelial growth (VEGF), heme oxygenase-1, inducible nitric oxide synthase, and the glycolytic enzymes aldolase A, enolase 1, lactate dehydrogenase A, phosphofructokinase I, and phosphoglycerate kinase 1. The C-terminal of HIF-1 alpha binds to p300. p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF.Host Species: Mouse
Clone: H1α67
Isotype: IgG2b/κ
Species Reactivity: Human, Sheep, Mouse, Rat and Ferret. Others not known.
Epitope: aa 432-528
Immunogen: Recombinant hHIF-1α (aa 432-528) protein
Molecular Weight: 120kDa
Positive Control: Mammalian cells cultured under reduced O2 tension
Cellular Localization: Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting (Not verified)
- Immunoprecipitation (Not verified)
Note:
USA: RUO; Int'l: RUO
Specifications
| HIF-1alpha (Hypoxia-Inducible Factor-1alpha) Ab-4 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 100 μL | |
| Transcription Regulation | |
| Ferret, Human, Mouse, Rat, Sheep | |
| IgG2b κ |
| Immunohistochemistry (Paraffin) | |
| H1alpha67 | |
| Unconjugated | |
| Recombinant hHIF-1alpha (aa 432-528) protein | |
| RUO | |
| Primary | |
| Concentrated |
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